MAD2L2
LOCUS ID10459
GENE_SYMBOLMAD2L2
GENE NAMEMAD2 mitotic arrest deficient-like 2 (yeast)
SYNONYMNSREV7, MAD2B, POLZ2
CHROMOSOME1
HOMOLOGENE ID4624
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of aphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. MAD2B may play an important role in high glucose-mediated podocyte injury of DN via modulation of Cdh1, cyclin B1, and Skp2 expression.25651564