MAPK7
LOCUS ID5598
GENE_SYMBOLMAPK7
GENE NAMEmitogen-activated protein kinase 7
SYNONYMNSBMK1, ERK4, ERK5, PRKM7
CHROMOSOME17
HOMOLOGENE ID2060
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical sigls, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar sigls, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four altertively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy. Hence, ERK5 may be a putative therapeutic target to modulate VEGF expression in diabetic retinopathy 2. Our experiments demonstrated a novel mechanism of glucose-induced increased FN production in diabetic retinopathy, which is mediated through decreased ERK5 sigling. 3. ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy. Hence, ERK5 may be a putative therapeutic target to modulate VEGF expression in diabetic retinopathy20671964 , 23188731 , 20671964