MARCO
LOCUS ID8685
GENE_SYMBOLMARCO
GENE NAMEmacrophage receptor with collagenous structure
SYNONYMNSSR-A6, SCARA2
CHROMOSOME2
HOMOLOGENE ID4928
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Tuberculosis1. Reduced MARCO and CD14 expression contributes to defective sentinel function of alveolar macrophages, promoting tuberculosis susceptibility in diabetic hosts at a critical early step in the immune response to aerosol infection27630197