| MBP |
| LOCUS ID | 4155 | ||||||||||
| GENE_SYMBOL | MBP | ||||||||||
| GENE NAME | myelin basic protein | ||||||||||
| SYNONYMNS | NA | ||||||||||
| CHROMOSOME | 18 | ||||||||||
| HOMOLOGENE ID | 1788 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Altertive splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-rel |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. The increased transcript levels of P0 and MBP suggest that Schwann cells can modulate gene expression of myelin-specific proteins in response to diabetic-induced metabolic derangement. Such a change may represent a higher turnover of myelin proteins as an attempt by the Schwann cells to repair the diabetes-induced nerve damage. The observed pattern of transcript amount is only slightly influenced by insulin treatment. | 8710212 |