| MGP |
| LOCUS ID | 4256 | ||||||||||
| GENE_SYMBOL | MGP | ||||||||||
| GENE NAME | This gene encodes a | ||||||||||
| SYNONYMNS | NTI, GIG36, MGLAP | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 91425 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Ke |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Decreasing the levels of matrix Gla protein entails an increase in coronary and renal artery calcification, which has the potential to increase cardiovascular events and accelerate decline in renal function. | 29790252 |