| MIF |
| LOCUS ID | 4282 | ||||||||||||||||
| GENE_SYMBOL | MIF | ||||||||||||||||
| GENE NAME | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | ||||||||||||||||
| SYNONYMNS | GIF, GLIF, MMIF | ||||||||||||||||
| CHROMOSOME | 22 | ||||||||||||||||
| HOMOLOGENE ID | 55655 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Immunofluorescence studies revealed that MIF was expressed in mouse kidney glomeruli. While MIF expression was enhanced in the diabetic kidneys of both mouse strains, the elevated secretion from db/db mouse kidneys may be responsible for initiating the onset of microalbuminuria in diabetic nephropathy. | 23649333 |
| Atherosclerosis | 1. MIF has been reported to contribute to the development of type 2 diabetes-related diseases such as atherosclerosis and cancer. | 16443889 |
| Neuropathy | 1. The serum pro-inflammatory cytokines MIF, TNF-alpha, and IL-6 levels play an important role in the pathogenesis of DM and diabetic peripheral neuropathy (DPN) | 19567096 |