MIF
LOCUS ID4282
GENE_SYMBOLMIF
GENE NAMEmacrophage migration inhibitory factor (glycosylation-inhibiting factor)
SYNONYMNSGIF, GLIF, MMIF
CHROMOSOME22
HOMOLOGENE ID55655
microRNAsNANA
GENE SUMMARY
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Immunofluorescence studies revealed that MIF was expressed in mouse kidney glomeruli. While MIF expression was enhanced in the diabetic kidneys of both mouse strains, the elevated secretion from db/db mouse kidneys may be responsible for initiating the onset of microalbuminuria in diabetic nephropathy.23649333
Atherosclerosis1. MIF has been reported to contribute to the development of type 2 diabetes-related diseases such as atherosclerosis and cancer.16443889
Neuropathy1. The serum pro-inflammatory cytokines MIF, TNF-alpha, and IL-6 levels play an important role in the pathogenesis of DM and diabetic peripheral neuropathy (DPN)19567096