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MIF |
LOCUS ID | 4282 | |||||||||||||||||||
GENE_SYMBOL | MIF | |||||||||||||||||||
GENE NAME | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | |||||||||||||||||||
SYNONYMNS | GIF, GLIF, MMIF | |||||||||||||||||||
CHROMOSOME | 22 | |||||||||||||||||||
HOMOLOGENE ID | 55655 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. Immunofluorescence studies revealed that MIF was expressed in mouse kidney glomeruli. While MIF expression was enhanced in the diabetic kidneys of both mouse strains, the elevated secretion from db/db mouse kidneys may be responsible for initiating the onset of microalbuminuria in diabetic nephropathy. | 23649333 |
Atherosclerosis | 1. MIF has been reported to contribute to the development of type 2 diabetes-related diseases such as atherosclerosis and cancer. | 16443889 |
Neuropathy | 1. The serum pro-inflammatory cytokines MIF, TNF-alpha, and IL-6 levels play an important role in the pathogenesis of DM and diabetic peripheral neuropathy (DPN) | 19567096 |
Dyslipidemia | 1. Metabolic syndrome is a complex clinical disorder characterized by obesity, a disturbance of glucose metabolism, dyslipidemia, and hypertension, leading to increased cardiovascular risk. Elevated levels of macrophage migration inhibitory factor in women with metabolic syndrome. | 21823060 |