MMP14
LOCUS ID4323
GENE_SYMBOLMMP14
GENE NAMEmatrix metallopeptidase 14 (membrane-inserted)
SYNONYMNSMMP-14, MMP-X1, MT-MMP, MT1MMP, MTMMP1, WNCHRS, MT1-MMP,
CHROMOSOME14
HOMOLOGENE ID21040
microRNAsNANA
GENE SUMMARY
Proteins of the matrix metalloproteise (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as ictive proproteins which are activated when cleaved by extracellular proteises. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These suggest that MMP-2 and MT1-MMP are produced and activated in glomeruli through the progression of diabetic nephropathy and may have some effect on the remodeling of the glomerular matrix in diabetic nephropathy.21414971