MOK
LOCUS ID5891
GENE_SYMBOLMOK
GENE NAMEMOK protein kinase
SYNONYMNSRAGE, RAGE1, STK30, RAGE-1
CHROMOSOME14
HOMOLOGENE ID8062
microRNAsNANA
GENE SUMMARY
This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestil crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple altertively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

OBSERVATIONS

Complication Evidence PMID
Atherosclerosis1. Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in accelerated atherosclerosis in diabetes.Serum levels of sRAGE are positively associated with MCP-1 and TNF-alpha levels in type 2 diabetic patients. These observations suggest the possibility that sRAGE level may become a novel biomarker of vascular inflammation in type 2 diabetic patients.17592553
Nephropathy1. The RAGE(2) haplotype is associated with DN in type 2 diabetics and with earlier DN onset and, thus, can be regarded a marker for DN.15790669
Dyslipidemia1. The up-regulation of RAGE was related to dyslipidemia and diabetic nephropathy.25324883