MRPL28
LOCUS ID10573
GENE_SYMBOLMRPL28
GENE NAMEmitochondrial ribosomal protein L28
SYNONYMNSp15, MAAT1
CHROMOSOME16
HOMOLOGENE ID4693
microRNAsNANA
GENE SUMMARY
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rR composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rR. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was origilly isolated by its ability to recognize tyrosise in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. HLA-A24 is not a protective factor for Proliferative diabetic retinopathy (PDR), but is a risk factor of its development.18040918