MT1A
LOCUS ID4489
GENE_SYMBOLMT1A
GENE NAMEmetallothionein 1A
SYNONYMNSMT1, MTC, MT1S
CHROMOSOME16
HOMOLOGENE IDNA
microRNAsNANA
GENE SUMMARY
NA

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. this work provides novel evidence on the association of the +647 A/C MT1A polymorphism with DM2. Moreover, C+ carriers in DCVD patients presented a worse glycemic control, a reduced iZnR and a higher MT levels, suggesting a possible role of MT in diabetic cardiovascular complications.18249147
Neuropathy1. Increased serum levels in diabetic patients were positively associated with rs964372 SNP, and type 2 diabetes with neuropathy was positively associated with rs10636 and rs11076161. These results suggest that multiple SNPs in MT genes are associated with diabetes and its clinical symptoms.MT1A gene in rs8052394 SNP is most likely the predisposition gene locus for diabetes or changes of serum superoxide dismutase activity.18349110