MTOR
LOCUS ID2475
GENE_SYMBOLMTOR
GENE NAMEmechanistic target of rapamycin (serine/threonine kinase)
SYNONYMNSFRAP, FRAP1, FRAP2, RAFT1, RAPT1
CHROMOSOME1
HOMOLOGENE ID3637
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as D damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Dysregulation of the TSC-mTOR pathway may cause not only tumor development but also metabolic disorders such as diabetes and its complications.18926585