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MyD88 |
LOCUS ID | 4615 | ||||||||||
GENE_SYMBOL | MyD88 | ||||||||||
GENE NAME | myeloid differentiation primary response 88 | ||||||||||
SYNONYMNS | NA | ||||||||||
CHROMOSOME | 3 | ||||||||||
HOMOLOGENE ID | 1849 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. significant increased risk of T2DM for the AG genotype of rs6853 in MyD88 gene.In conclusion, our results indicate that the polymorphisms in TLR-MyD88-NF- kappa B signaling pathway confer genetic susceptibility to T2DM and DN. | 27062898 |