MyD88
LOCUS ID4615
GENE_SYMBOLMyD88
GENE NAMEmyeloid differentiation primary response 88
SYNONYMNSNA
CHROMOSOME3
HOMOLOGENE ID1849
microRNAsNANA
GENE SUMMARY
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. significant increased risk of T2DM for the AG genotype of rs6853 in MyD88 gene.In conclusion, our results indicate that the polymorphisms in TLR-MyD88-NF- kappa B signaling pathway confer genetic susceptibility to T2DM and DN.27062898