NAGLU
LOCUS ID4669
GENE_SYMBOLNAGLU
GENE NAMEN-acetylglucosaminidase, alpha
SYNONYMNSNAG, CMT2V, MPS3B, UFHSD, MPS-IIIB
CHROMOSOME17
HOMOLOGENE ID222
microRNAsNANA
GENE SUMMARY
This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. The current study emphasizes a strong association of the tubular biomarkers NAG and KIM-1 with CKD progression in chronic heart failure and suggests their usefulness as cardiorenal markers.26422793
Retinopathy1. The suggest that both serum NAG activity and albuminuria may serve as early functional indicators of diabetic retinopathy.1837508