NCF1
LOCUS ID653361
GENE_SYMBOLNCF1
GENE NAMEnuclear factor, erythroid 2
SYNONYMNSp45, NF-E2
CHROMOSOME12
HOMOLOGENE ID4491
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil DPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The NF-E2-related factor 2-mediated protection against diabetic nephropathy is, at least partially, through inhibition of TGF-beta 1 and reduction of extracellular matrix production. Studies show activation or overexpression of NRF2 inhibits the promoter activity of TGF- beta 1, whereas knockdown of NRF2 by small interfering RNA enhances TGF-beta 1 transcription.24072144
Tuberculosis1. The sequential evaluation of the mRNA levels of NCF1 and ORM as multiple diagnostic tests showed 95% Sensitivity (Se) and 80% Specificity (Sp). In addition, FPR2 promises to be a good biomarker for the PTB detection in subjects with NIDDM26628192