NCF2
LOCUS ID4688
GENE_SYMBOLNCF2
GENE NAMEnuclear factor, erythroid 2-like 2
SYNONYMNSNRF2, HEBP1
CHROMOSOME2
HOMOLOGENE ID2412
microRNAsNANA
GENE SUMMARY
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein DPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other DPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Altertive splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Renal mRNA s and protein expressions of NF-E2 related factor 2 (Nrf2) were up-regulated by MG132 in comparison to DN alone.21241714