NGF
LOCUS ID4803
GENE_SYMBOLNGF
GENE NAMEnerve growth factor (beta polypeptide)
SYNONYMNSNGFB, HSAN5, Beta-NGF
CHROMOSOME1
HOMOLOGENE ID1876
microRNAsNANA
GENE SUMMARY
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. NGF levels correlated well with diabetes duration, HbA1c, and blood sugar levels and diabetic nephropathy.18282491
Neuropathy1. These findings suggest that decreased levels of NGF in diabetic sciatic nerves may be involved in the pathogenesis of diabetic neuropathy in rats9628756