| NGF |
| LOCUS ID | 4803 | ||||||||||||||||
| GENE_SYMBOL | NGF | ||||||||||||||||
| GENE NAME | nerve growth factor | ||||||||||||||||
| SYNONYMNS | NGFB, HSAN5, Beta-NGF | ||||||||||||||||
| CHROMOSOME | 1 | ||||||||||||||||
| HOMOLOGENE ID | 1876 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. NGF levels correlated well with diabetes duration, HbA1c, and blood sugar levels and diabetic nephropathy. | 18282491 |
| Neuropathy | 1. These findings suggest that decreased levels of NGF in diabetic sciatic nerves may be involved in the pathogenesis of diabetic neuropathy in rats | 9628756 |
| Insulin resistance and inflammation | 1. The specific pathogenic pathways of MetSyn development include: (1) increased tissue and plasma levels of proinflammatory cytokines Interleukin-1(IL-1), Interleukin-6 (IL-6 ) and tumor necrosis factor - alpha (TNF-alpha) caused by inflammatory and/or emotional distress; (2) increased plasma levels of neurotrophin - nerve growth factor (NGF) caused by the high IL-1, IL-6 and TNFalpha levels; (3) high plasma levels of NGF which enhance activation of: the autonomous nerve system--vegetodystonia (disbalance of neurotransmitters); Neuropeptide Y (NPY)--enhanced feeding, obesity and increased leptin plasma levels; hypothalamo-pituitary-adrenal axis--increased corticotropin-releasing hormone (CRH) and cortisol (hormonal disbalance); immune cells--increased number and degranulation of mastocytes (MC)--immunological disbalance; (4) as a result of 1-3 insulin resistance is exhibited leading to diabetes mellitus. | 16298496 |