NGFR
LOCUS ID4804
GENE_SYMBOLNGFR
GENE NAMEnerve growth factor receptor
SYNONYMNSCD271, p75NTR, TNFRSF1
CHROMOSOME17
HOMOLOGENE ID1877
microRNAsNANA
GENE SUMMARY
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Increased nerve hydration and increased expression of low affinity p75 receptor for neurotrophins suggest new therapeutic potentials for the prevention of diabetic neuropathy.9330882