| NGFR |
| LOCUS ID | 4804 | ||||||||||
| GENE_SYMBOL | NGFR | ||||||||||
| GENE NAME | nerve growth factor | ||||||||||
| SYNONYMNS | CD271, p75NTR, TNFRSF1 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 1877 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. Increased nerve hydration and increased expression of low affinity p75 receptor for neurotrophins suggest new therapeutic potentials for the prevention of diabetic neuropathy. | 9330882 |