| NOS1 |
| LOCUS ID | 4842 | ||||||||||||||||
| GENE_SYMBOL | NOS1 | ||||||||||||||||
| GENE NAME | nitric oxide synthas | ||||||||||||||||
| SYNONYMNS | NOS, bNOS, nNOS, IHPS1, N-NOS, NC-NOS | ||||||||||||||||
| CHROMOSOME | 12 | ||||||||||||||||
| HOMOLOGENE ID | 37327 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Nitric oxide synthase 1 (NOS1) 5' haplotype (TGTC frequency = 0.38) also revealed a suggestive association with diabetic nephropathy heterozygous 1.26 (0.95-1.67), homozygous 1.57 (1.04-2. 35) (p = 0.0073). | 19415232 |
| Retinopathy | 1. These suggest that increased nNOS activity is responsible for the majority of increased NO in retinal neurons in early diabetic retinopathy. 2. The alterations in eNOS, nNOS and iNOS expression are associated with the deuelopmant and progression of DR. | 19936028 |
| Neuropathy | 1. Immunohistochemical evaluation of NOS1 activity showed intense staining of the fibres of the DNP and most of the neurones in the main pelvic ganglion. There was also scattered NOS1 activity in the nerve bundles of the corpus cavernosum. 2. This study provides a useful template for future studies of experimental diabetic autonomic neuropathy. | 17378850 |