| NOX3 |
| LOCUS ID | 50508 | |||||||||||||
| GENE_SYMBOL | NOX3 | |||||||||||||
| GENE NAME | DPH oxidase 3 | |||||||||||||
| SYNONYMNS | MOX-2, GP91-3 | |||||||||||||
| CHROMOSOME | 6 | |||||||||||||
| HOMOLOGENE ID | 49435 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the NOX family of DPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membran |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Potential candidate genes in these regions that have been implicated in diabetic nephropathy and/or renal damage in models of hypertension include CYBA (or P22PHOX) (16q24), NOX1 (10q22), and NOX3 (6q25.1-q26) | 17336700 |
| Insulin resistance and inflammation | 1. NOX3 expression is induced in differentiated 3T3-L1 adipocytes upon treatment with proinflammatory cytokines. | 30317185 |