| NPY5R |
| LOCUS ID | 4889 | ||||||||||
| GENE_SYMBOL | NPY5R | ||||||||||
| GENE NAME | neuropeptide Y recep | ||||||||||
| SYNONYMNS | NPYR5, NPY5-R, NPYY5-R | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 21241 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Cardiovascular | 1. Gene expression of NPY2R, NPY5R, preproTachykinin A (SP gene), and NK1R and their respective protein expression were significantly reduced whereas that of NPY and NPY1R were unchanged in the right atrium of diabetic patients compared to nondiabetic patients. | 22029806 |