| NQO1 |
| LOCUS ID | 1728 | |||||||||||||
| GENE_SYMBOL | NQO1 | |||||||||||||
| GENE NAME | D(P)H dehydrogenas | |||||||||||||
| SYNONYMNS | DTD, QR1, DHQU, DIA4, NM | |||||||||||||
| CHROMOSOME | 16 | |||||||||||||
| HOMOLOGENE ID | 695 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is a member of the D(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Cardiovascular | 1. These suggest that the C609T polymorphism of NQO1 is associated with carotid artery plaques in type 2 diabetic patients | 19251446 |
| Atherosclerosis | 1. These suggest that the C609T polymorphism of NQO1 is associated with carotid artery plaques in type 2 diabetic patients. | 19251446 |