NR1H3
LOCUS ID10062
GENE_SYMBOLNR1H3
GENE NAMEnuclear receptor subfamily 1, group H, member 3
SYNONYMNSLXRA, LXR-a, RLD-1
CHROMOSOME11
HOMOLOGENE ID21165
microRNAsmiR-15523991091
GENE SUMMARY
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Altertively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. LXR stimulation by GW3965 up-regulated genes involved in cholesterol efflux and down-regulated proinflammatory/profibrotic cytokines, inhibiting the pathomorphology of diabetic nephropathy, renal lipid accumulation, and improving renal function. Xanthine oxidoreductase and nitrotyrosine levels were reduced.23318573