| NR1H3 |
| LOCUS ID | 10062 | ||||||||||
| GENE_SYMBOL | NR1H3 | ||||||||||
| GENE NAME | nuclear receptor sub | ||||||||||
| SYNONYMNS | LXRA, LXR-a, RLD-1 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 21165 |
| microRNAs | miR-155 | 23991091 |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. LXR stimulation by GW3965 up-regulated genes involved in cholesterol efflux and down-regulated proinflammatory/profibrotic cytokines, inhibiting the pathomorphology of diabetic nephropathy, renal lipid accumulation, and improving renal function. Xanthine oxidoreductase and nitrotyrosine levels were reduced. | 23318573 |