| NRF1 |
| LOCUS ID | 4899 | ||||||||||
| GENE_SYMBOL | NRF1 | ||||||||||
| GENE NAME | nuclear respiratory | ||||||||||
| SYNONYMNS | ALPHA-PAL | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 3674 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial D transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Altertive splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. PGC-1a and its-regulated transcription factors including TFAM and NRF1, which are master regulators of mitochondrial biogenesis, are significantly downregulated in streptozotocin diabetic dorsal root ganglion (DRG) neurons. | 24423644 |