NRF1
LOCUS ID4899
GENE_SYMBOLNRF1
GENE NAMEnuclear respiratory factor 1
SYNONYMNSALPHA-PAL
CHROMOSOME7
HOMOLOGENE ID3674
microRNAsNANA
GENE SUMMARY
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial D transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Altertive splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. PGC-1a and its-regulated transcription factors including TFAM and NRF1, which are master regulators of mitochondrial biogenesis, are significantly downregulated in streptozotocin diabetic dorsal root ganglion (DRG) neurons.24423644