NRG4
LOCUS ID145957
GENE_SYMBOLNRG4
GENE NAMEneuregulin 4
SYNONYMNSHRG4
CHROMOSOME15
HOMOLOGENE ID12921
microRNAsNANA
GENE SUMMARY
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. These findings together suggested that circulating Nrg4 levels were reduced in DPN patients and Nrg4 may be a novel adipokine associated with inflammation, oxidative stress, and long-term glycemic control in nT2DM patients.30322810