| NRG4 |
| LOCUS ID | 145957 | |||||||||||||
| GENE_SYMBOL | NRG4 | |||||||||||||
| GENE NAME | neuregulin 4 | |||||||||||||
| SYNONYMNS | HRG4 | |||||||||||||
| CHROMOSOME | 15 | |||||||||||||
| HOMOLOGENE ID | 12921 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. These findings together suggested that circulating Nrg4 levels were reduced in DPN patients and Nrg4 may be a novel adipokine associated with inflammation, oxidative stress, and long-term glycemic control in nT2DM patients. | 30322810 |
| Insulin resistance and inflammation | 1. Using the hydrodynamic gene transfer method, we demonstrate that Nrg4 gene transfer in mice suppressed the development of diet-induced obesity, but did not affect pre-existing adiposity and body weight in obese mice. | 27184920 |