NTF3
LOCUS ID4908
GENE_SYMBOLNTF3
GENE NAMEneurotrophin 3
SYNONYMNSNT3, HDNF, NGF2, NT-3, NGF-2
CHROMOSOME12
HOMOLOGENE ID1896
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintence of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. expression of NT-3 is reduced in striated muscles in diabetic patients and is related to muscle weakness and neuropathy. We suggest that lack of NT-3 contributes to insufficient re-innervation leading to the loss of muscle strength in diabetic neuropathy.19696031