NUCB2
LOCUS ID4925
GENE_SYMBOLNUCB2
GENE NAMEnucleobindin 2
SYNONYMNSNEFA, HEL-S-109
CHROMOSOME11
HOMOLOGENE ID3676
microRNAsNANA
GENE SUMMARY
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. In fully adjusted covariates, serum NEFA was an independent risk factor for all-cause mortality (hazard ratio [HR] per log2 increase, 1.22; 95% confidence interval [95% CI], 1.00 to 1.48) and CVD-related death (HR, 1.51; 95% CI, 1.15 to 1.99), including both IHD (HR, 1.51; 95% CI, 1.00 to 2. 32) and AMI mortality (HR, 2. 08; 95% CI, 1.09 to 3. 98).25637632
Retinopathy1. The difference reached statistical significance in probands with DR and probands without DR (p<0.0001). Nonesterified fatty acid (NEFA) was a risk factor for DR (odds ratio = 2.108, 95% confidence interval 1.077-4.127).20306445