ONECUT1
LOCUS ID3175
GENE_SYMBOLONECUT1
GENE NAMEone cut homeobox 1
SYNONYMNSHNF6, HNF-6, HNF6A
CHROMOSOME15
HOMOLOGENE ID3309
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Histological analysis of the HNF6 kidneys displayed diabetic glomerular changes, including glomerular enlargement, diffuse mesangial proliferation and matrix expansion, thickened glomerular basement membrane, and arteriolar hyalinosis.Thus the HNF6 mouse exhibits diabetic renal changes that parallel the early phase of human DN16705146