P2RX3
LOCUS ID5024
GENE_SYMBOLP2RX3
GENE NAMEpurinergic receptor P2X 3
SYNONYMNSP2X3
CHROMOSOME11
HOMOLOGENE ID1922
microRNAsNANA
GENE SUMMARY
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling Urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Purinergic receptor signaling transduction pathways might become potential targets for treatment for painful DPN.23090494