P2RY1
LOCUS ID5028
GENE_SYMBOLP2RY1
GENE NAMEpurinergic receptor P2Y1
SYNONYMNSP2Y1
CHROMOSOME3
HOMOLOGENE ID1926
microRNAsNANA
GENE SUMMARY
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Purinergic receptor signaling transduction pathways might become potential targets for treatment for painful DPN.23090494