P2RY2
LOCUS ID5029
GENE_SYMBOLP2RY2
GENE NAMEpurinergic receptor P2Y2
SYNONYMNSP2U, HP2U, P2U1, P2UR, P2Y2, P2RU1, P2Y2R
CHROMOSOME11
HOMOLOGENE ID1927
microRNAsNANA
GENE SUMMARY
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Purinergic receptor signaling transduction pathways might become potential targets for treatment for painful DPN.23090494