PAK5
LOCUS ID57144
GENE_SYMBOLPAK5
GENE NAMEp21 protein (Cdc42/Rac)-activated kinase 7
SYNONYMNSPAK7
CHROMOSOME20
HOMOLOGENE ID22211
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dymics, proliferation, and cell survival sigling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predomintly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Altertively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. RSK4 and PAK5 may provide a molecular ratiole for late-stage complications in disease, and further studies are warranted to explore these targets for the treatment of diabetic nephro- and neuropathy, frequently seen in patients with HNF4alpha dysfunction.15615695