PAK6
LOCUS ID56924
GENE_SYMBOLPAK6
GENE NAMEp21 protein (Cdc42/Rac)-activated kinase 6
SYNONYMNSPAK5
CHROMOSOME15
HOMOLOGENE ID23200
microRNAsNANA
GENE SUMMARY
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-termil Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-termil kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. RSK4 and PAK5 may provide a molecular ratiole for late-stage complications in disease, and further studies are warranted to explore these targets for the treatment of diabetic nephro- and neuropathy, frequently seen in patients with HNF4alpha dysfunction.15615695