PDK1
LOCUS ID5163
GENE_SYMBOLPDK1
GENE NAMEpyruvate dehydrogenase kinase 1
SYNONYMNSNA
CHROMOSOME2
HOMOLOGENE ID134437
microRNAsNANA
GENE SUMMARY
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in ictivation. Multiple altertively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Interestingly, PDK1 was downregulated in the glomeruli of diabetic rats and patients with type 2 diabetes before the onset of proteinuria, further suggesting that reduced expression of PDK1 associates with podocyte injury and development of DN.25950482