PEBP1
LOCUS ID5037
GENE_SYMBOLPEBP1
GENE NAMEphosphatidylethanolamine binding protein 1
SYNONYMNSPBP, HCNP, PEBP, RKIP, HCNPpp, PEBP-1, HEL-210, HEL-S-34
CHROMOSOME12
HOMOLOGENE ID37637
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These suggest that expression levels of RKIP might be regulated by RTX via NF-kappaB. This pathway could play an important role in the development and pathogenesis of DN.24065653