| PFKFB2 |
| LOCUS ID | 5208 | ||||||||||
| GENE_SYMBOL | PFKFB2 | ||||||||||
| GENE NAME | 6-phosphofructo-2-ki | ||||||||||
| SYNONYMNS | PFK-2/FBPase-2 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 88554 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The activation of PDGFR-beta siglling contributes to the progress of diabetic nephropathy, with an increase in oxidative stress and mesangial expansion in CaMKII-alpha mice 2. Variation in PFKFB2 appears to reduce PFKFB2 expression in adipose and kidney tissues, and thereby increase risk for adiposity and DN | 21833587 |