PFKFB2
LOCUS ID5208
GENE_SYMBOLPFKFB2
GENE NAME6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
SYNONYMNSPFK-2/FBPase-2
CHROMOSOME1
HOMOLOGENE ID88554
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The activation of PDGFR-beta siglling contributes to the progress of diabetic nephropathy, with an increase in oxidative stress and mesangial expansion in CaMKII-alpha mice 2. Variation in PFKFB2 appears to reduce PFKFB2 expression in adipose and kidney tissues, and thereby increase risk for adiposity and DN21833587 , 12048257