PIGF
LOCUS ID5281
GENE_SYMBOLPIGF
GENE NAMEphosphatidylinositol glycan anchor biosynthesis class F
SYNONYMNSNA
CHROMOSOME2
HOMOLOGENE ID31103
microRNAsNANA
GENE SUMMARY
This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Altertively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. These strongly implicate a role for PIGF in the pathogenesis of proliferative diabetic retinopathy.9461127