PNPLA3
LOCUS ID80339
GENE_SYMBOLPNPLA3
GENE NAMEpatatin like phospho
SYNONYMNSADPN,C22orf20,iPLA(2)epsilon
CHROMOSOME22
HOMOLOGENE ID11883
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. Obese/Metabolic NAFLD due to the PNPLA3 or TM6SF2 genetic variants predisposes to type 2 diabetes and cardiovascular disease.27128911
Insulin resistance and inflammation1. Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409.27929200