PON2
LOCUS ID5445
GENE_SYMBOLPON2
GENE NAMEparaoxose 2
SYNONYMNSNA
CHROMOSOME7
HOMOLOGENE ID385
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the paraoxose gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Altertively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. PON2 variants typed in this study have, at best, a small effect on the risk of renal dysfunction in type 2 diabetes.17096118
Atherosclerosis1. macrophages from diabetic mice demonstrate increased oxidative stress associated with activation of DPH oxidase and up-regulation of cellular PON2, as well as increased macrophages cholesterol uptake and biosynthesis (increased expression of CD-36 and HMG-CoA reductase).17258748