PPARGC1A
LOCUS ID10891
GENE_SYMBOLPPARGC1A
GENE NAMEperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
SYNONYMNSLEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1(alpha)
CHROMOSOME4
HOMOLOGENE ID7485
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between exterl physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determition. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The Gly482Ser polymorphism of the PPARGC1A gene is associated with DN in Asian Indians.19900151
Cardiovascular1. We propose that PPARGC1A influences development of type 2 diabetes and CVD via D damage18162502
Retinopathy1. The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between exterl physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determition. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.15782399
Neuropathy1. PGC-1a and its-regulated transcription factors including TFAM and NRF1, which are master regulators of mitochondrial biogenesis, are significantly downregulated in streptozotocin diabetic dorsal root ganglion (DRG) neurons.24423644