PPY
LOCUS ID5539
GENE_SYMBOLPPY
GENE NAMEpancreatic polypeptide
SYNONYMNSPP, PNP
CHROMOSOME17
HOMOLOGENE ID2039
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestil functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Altertive splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Measuring PP serum levels in diabetics after a protein rich meal can be useful to check vagus nerve function in the gastrointestil tract in order to detect autonomic neuropathy.7739457