PRKAA1
LOCUS ID5562
GENE_SYMBOLPRKAA1
GENE NAMEprotein kinase, AMP-activated, alpha 1 catalytic subunit
SYNONYMNSAMPK, AMPKa1
CHROMOSOME5
HOMOLOGENE ID49590
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Altertively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. There was haplotype association of PRKAA2 rs10789038-rs2796498-rs2746342 with T2DM susceptibility. In addition, rs2796498 was found to be related to the susceptibility to diabetic nephropathy.20332614