PRKAA2
LOCUS ID5563
GENE_SYMBOLPRKAA2
GENE NAMEprotein kinase AMP-activated catalytic subunit alpha 2
SYNONYMNSAMPK,AMPK2,PRKAA,AMPKa2
CHROMOSOME1
HOMOLOGENE ID4551
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
NephropathyNA28322508