| PRKAA2 |
| LOCUS ID | 5563 | ||||||||||
| GENE_SYMBOL | PRKAA2 | ||||||||||
| GENE NAME | protein kinase AMP-a | ||||||||||
| SYNONYMNS | AMPK,AMPK2,PRKAA,AMPKa2 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 4551 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involve |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | NA | 28322508 |