PROC
LOCUS ID5624
GENE_SYMBOLPROC
GENE NAMEprotein C (inactivator of coagulation factors Va and VIIIa)
SYNONYMNSPC, APC, PROC1, THPH3, THPH4
CHROMOSOME2
HOMOLOGENE ID37288
microRNAsNANA
GENE SUMMARY
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neotal purpura fulmins, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. A protective effect of activated PC in diabetic nephropathy is established.23014597