| PROC |
| LOCUS ID | 5624 | ||||||||||
| GENE_SYMBOL | PROC | ||||||||||
| GENE NAME | protein C (inactivat | ||||||||||
| SYNONYMNS | PC, APC, PROC1, THPH3, THPH4 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 37288 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neotal purpura fulmins, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. A protective effect of activated PC in diabetic nephropathy is established. | 23014597 |