PROM1
LOCUS ID8842
GENE_SYMBOLPROM1
GENE NAMEprominin 1
SYNONYMNSRP41, AC133, CD133, MCDR2, STGD4, CORD12, PROML1, MSTP061
CHROMOSOME4
HOMOLOGENE ID4390
microRNAsNANA
GENE SUMMARY
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five altertive promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. CD34+ CPC are reduced in diabetes with advanced complications and diabetic foot. CD34+KDR+ and CD31+133+ EPC differentiation could have a prognostic and therapeutic significance in the healing process of neuropathic and neuroischemic lesions.24624298