PSMA6
LOCUS ID5687
GENE_SYMBOLPSMA6
GENE NAMEproteasome (prosome, macropain) subunit, alpha type, 6
SYNONYMNSIOTA, p27K, PROS27
CHROMOSOME14
HOMOLOGENE ID2085
microRNAsNANA
GENE SUMMARY
The proteasome is a multicatalytic proteise complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. abundance of the PSMA6 protein was significantly reduced in the renal cortex of both STZ-induced and spontaneous OLETF diabetic rats.20651835
Cardiovascular1. PSMA6 rs_1048990 polymorphism may contribute to myocardial infarction (MI) susceptibility in type 2 diabetes18358479