| PSMA6 |
| LOCUS ID | 5687 | |||||||||||||
| GENE_SYMBOL | PSMA6 | |||||||||||||
| GENE NAME | proteasome (prosome, | |||||||||||||
| SYNONYMNS | IOTA, p27K, PROS27 | |||||||||||||
| CHROMOSOME | 14 | |||||||||||||
| HOMOLOGENE ID | 2085 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The proteasome is a multicatalytic proteise complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. abundance of the PSMA6 protein was significantly reduced in the renal cortex of both STZ-induced and spontaneous OLETF diabetic rats. | 20651835 |
| Cardiovascular | 1. PSMA6 rs_1048990 polymorphism may contribute to myocardial infarction (MI) susceptibility in type 2 diabetes | 18358479 |