PTEN
LOCUS ID5728
GENE_SYMBOLPTEN
GENE NAMEphosphatase and tensin homolog
SYNONYMNSBZS, DEC, CWS1, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10
CHROMOSOME10
HOMOLOGENE ID265
microRNAsmiR-21/15222956257, 26996529
GENE SUMMARY
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The suggest the following molecular etiopathophysiology of DN(i) hyperglycemia upregulates IGF2, which initiates PTEN, a regulator of IGF2 sigling; (ii) loss of this IGF2-PTEN feedback loop causes changes that are characteristic of DN; and (iii) lowered expression of the repair modulator SPARC in the development and/or progression of DN. Hence, targeting relevant modulators, such as like IGF2, PTEN, and SPARC, may be important in the magement of DN.20929508
Neuropathy1. Collectively, these findings identify a novel therapeutic approach, potentially applicable to other neurological conditions requiring specific forms of molecular knockdown, and also identify a unique target, PTEN, to treat diabetic neuroregenerative failure.24578546