| PTGDS |
| LOCUS ID | 5730 | |||||||||||||
| GENE_SYMBOL | PTGDS | |||||||||||||
| GENE NAME | prostaglandin D2 syn | |||||||||||||
| SYNONYMNS | PDS, PGD2, PGDS, LPGDS, PGDS2, L-PGDS | |||||||||||||
| CHROMOSOME | 9 | |||||||||||||
| HOMOLOGENE ID | 737 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this ge |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. lipocalin-type prostaglandin D(2) synthase (L-PGDS) knockout mice become glucose intolerant and display signs of diabetic nephropathy and accelerated atherosclerosis. | 18619553 |
| Atherosclerosis | 1. we demonstrated that lipocalin-type prostaglandin D(2) synthase (L-PGDS) knockout mice become glucose intolerant and display signs of diabetic nephropathy and accelerated atherosclerosis. | 18619553 |