PTGES
LOCUS ID9536
GENE_SYMBOLPTGES
GENE NAMEprostaglandin E synthase
SYNONYMNSPGES, MPGES, PIG12, PP102, PP1294, MGST-IV, MGST1L1, TP53
CHROMOSOME9
HOMOLOGENE ID3587
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1.an inhibitory effect of PPAR gamma activation on renal mPGES-1/PGE2/EP4 pathway in type-2 diabetes and suggested that mPGES-1 may potentially serve as a therapeutic target for treating type-2 diabetes-associated DN.24489534