PVT1
LOCUS ID5820
GENE_SYMBOLPVT1
GENE NAMEPvt1 oncogene (non-protein coding)
SYNONYMNSLINC00079, NCR00079
CHROMOSOME8
HOMOLOGENE IDNA
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as D damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These indicate that PVT1 may mediate the development and progression of diabetic nephropathy through mechanisms involving extracellular matrix (ECM) accumulation.21526116