REG1A
LOCUS ID5967
GENE_SYMBOLREG1A
GENE NAMEregenerating islet-derived 1 alpha
SYNONYMNSP19, PSP, PTP, REG, ICRF, PSPS, PSPS1
CHROMOSOME2
HOMOLOGENE ID68282
microRNAsNANA
GENE SUMMARY
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Urinary PSP excretion was increased from the initial stage of diabetic nephropathy and this increase became more marked as nephropathy progressed.9678681